The influence of tetracyclines on T cell activation
作者： M. KLOPPENBURG , C. L. VERWEIJ , A. M. M. MILTENBURG , A. J. VERHOEVEN , M. R. DAHA
DOI: 10.1111/J.1365-2249.1995.TB03864.X
关键词:
摘要: Minocycline has been shown to have an anti-inflammatory effect in patients with rheumatoid arthritis (RA). Since there is evidence that RA a T cell-mediated disease, we investigated the of minocycline on human cell clones derived from synovium patient. The cells, when activated via receptor (TCR)/CD3 complex, were suppressed functionally by minocycline, resulting dose-dependent inhibition proliferation and reduction production IL-2, interferon-gamma (IFN-gamma) tumour necrosis factor-alpha (TNF-alpha). Besides IL-2 production, exerted its induction decreased responsiveness. We showed chelating capacity plays crucial role inhibitory function, since could be annulled addition exogenous Ca2+. However, did not markedly influence typical TCR/CD3-induced intracellular Ca2+ mobilization. Taken together, results clearly indicate immunomodulating effects cells.
sci-hub.se 参考文章(39)
I. Engelberts, W. A. Buurman, A. Moller, G. J. M. Schoen, C. J. Van Der Linden, Evaluation of measurement of human TNF in plasma by ELISA. Lymphokine and cytokine research. ,vol. 10, pp. 69- 76 ,(1991)
Hugh Macdonald, Robert G. Kelly, E. Stewart Allen, John F. Noble, Leon A. Kanegis, Pharmacokinetic studies on minocycline in man Clinical Pharmacology & Therapeutics. ,vol. 14, pp. 852- 861 ,(1973) , 10.1002/CPT1973145852
R C Potts, J H Gibbs, J S Beck, R A Brown, H A Hassan, A J Robertson, A MacConnachie, In vitro effects of doxycycline and tetracycline on mitogen stimulated lymphocyte growth. Clinical and Experimental Immunology. ,vol. 53, pp. 458- 464 ,(1983)
G.M. Pepper, B.S. Schneider, J. Maimon, Quantification and characterization of ACTH-related peptides produced by human peripheral blood mononuclear cells. Lymphokine and cytokine research. ,vol. 10, pp. 133- 140 ,(1991)
N S Ramamurthy, L M Golub, R A Greenwald, S A Moak, Tetracyclines suppress matrix metalloproteinase activity in adjuvant arthritis and in combination with flurbiprofen, ameliorate bone damage. The Journal of Rheumatology. ,vol. 19, pp. 927- 938 ,(1992)
A Ferrante, Y H Thong, Inhibition of mitogen-induced human lymphocyte proliferative responses by tetracycline analogues. Clinical and Experimental Immunology. ,vol. 35, pp. 443- ,(1979)
Breedveld Fc, Dijkmans Ba, Mattie H, Minocycline treatment for rheumatoid arthritis: an open dose finding study. The Journal of Rheumatology. ,vol. 17, pp. 43- ,(1990)
R. C. Dow, Judith K. Park, The uptake and localization of tetracycline in human blood cells. British journal of experimental pathology. ,vol. 51, pp. 179- 182 ,(1970)
L Koenderman, A J Verhoeven, D Roos, M Yazdanbakhsh, Dual mechanisms in priming of the chemoattractant-induced respiratory burst in human granulocytes. A Ca2+-dependent and a Ca2+-independent route. Journal of Immunology. ,vol. 142, pp. 623- 628 ,(1989)
A Ferrante, Y H Thong, Effect of tetracycline treatment on immunological responses in mice. Clinical and Experimental Immunology. ,vol. 39, pp. 728- ,(1980)