Clinical and Microbiological Evaluation of a Bioabsorbable and a Nonresorbable Barrier Membrane in the Treatment of Periodontal Intraosseous Lesions

摘要: Clinical and microbiological features of periodontal healing in barrier membrane-treated sites were determined a randomized clinical trial. The study included 10 patients with advanced adult periodontitis minimum one set similar 2 to 3 wall intraosseous lesions no furcation involvement. In each patient, lesion was treated biodegradable membrane contralateral nonresorbable membrane. Within the preceding months regenerative therapy, all received full mouth osseous surgery except for regeneration, instructed oral hygiene, prescribed systemic ciprofloxacin metronidazole (250 mg each, TID, 8 days), starting 7 days before placement. At baseline at 6 postsurgery, probing depth attachment level assessed site. subgingival presence suspected pathogens by non-selective selective culture DNA probe analyses, human cytomegalovirus (HCMV) Epstein-Barr virus type 1 (EBV-1) nested-polymerase chain reaction detection method. baseline, barrier-treated did not differ significantly microbial parameters. Mean 7.8+/-1.1 mm bioabsorbable 7.9+/-1.3 sites. months, revealed 4.6+/-1.7 gain (range: mm) 4.2+/-2.0 mm). 11 that harbored 10% or less bacterial free HCMV EBV-1 averaged more than 9 yielded and/or test viruses (5.6 versus 3.0 mm; P=0.005). present data suggest barriers provide lesions, emphasize importance controlling prior during healing, point possible detrimental role repair.