Long-term administration of Clarithromycin for an asthmatic patient with mucosal abnormalities of sinonasal cavity

摘要: We experienced a case of 59-year-old woman with intractable asthma, who had aspirin intolerance. Despite various treatments including systemic corticosteroid administration, she was often admitted due to severe asthma attacks. Furthermore, allergic rhinitis and sinusitis. Computed tomography (CT) scans sinonasal cavity revealed marked thickness nasal mucosa air-fluid level in maxillary sinuses. Although her symptoms such as wheezing dyspnea were improved by administration bronchodilator, corticosteroids beclomethasone diisoccyanate (BDI) accompanied spa therapy, peak expiratory flow (PEF) showed no improvement. After readmission attacks, clarithromycin (CAM) administration for disorders started. The PEF value improvement after starting CAM pulmonary functions bronchial hyperresponsiveness also improved. It is suggested from clinical course that may have beneficial effects asthmatic patients disorders.