Increased cancellous bone remodeling during lactation in beagles.

摘要: Changes in bone mass and cancellous remodeling parameters were determined during lactation adult beagles. Bone mineral content was by photon absorptiometry, fraction of mineralized area perimeter to ratios image analysis microradiographs, fluorochrome-based histomorphometry. the intact proximal humerus tissue areas lumbar vertebral decreased when compared with controls. There significant increases osteoid volumes surface, although seam thickness not changed. fluorochrome-labeled surfaces lactating dogs The mineralizing formation rate activation frequency significantly increased also resorption lactation. These data indicate that lactation, turnover is increased. Increased a longer-lived mammal may represent an example "reversible deficit" which be important physiological mechanism nursing mothers ensure adequate calcium for milk production. provide enhance capacity skeleton better accommodate greatly episodic changes homeostasis