Circadian Rest-Activity Rhythm in Pediatric Type 1 Narcolepsy

摘要: STUDY OBJECTIVES Pediatric type 1 narcolepsy is often challenging to diagnose and remains largely undiagnosed. Excessive daytime sleepiness, disrupted nocturnal sleep, a peculiar phenotype of cataplexy are the prominent features. The knowledge available about regulation circadian rhythms in affected children scarce. This study compared rest-activity rhythm actigraphic estimated sleep measures with versus healthy controls. METHODS Twenty-two drug-naive 21 age- sex- matched controls were monitored for seven days during school week by actigraphy. Circadian activity analyzed through functional linear modeling; diurnal from using validated algorithm. RESULTS Children presented an altered characterized enhanced motor throughout night blunted first afternoon. No difference was found between timing phase. Actigraphic showed good discriminant capabilities assessing nycthemeral disruption. CONCLUSIONS Actigraphy reliably renders disruption typical recent disease onset, indicating sensibility assessment diagnostic work-up childhood 1.