The borderline or weakly positive Hybrid Capture II HPV test: A statistical and comparative (PCR) analysis
作者： Jerome M. Federschneider , Liping Yuan , Joshua Brodsky , Gillian Breslin , Rebecca A. Betensky
DOI: 10.1016/J.AJOG.2004.03.077
关键词:
摘要: Abstract Objectives Recent studies have hypothesized that laboratory contamination may influence interpretation of Hybrid Capture II (HCII) human papillomavirus (HPV) detection assay values. Study design To test this hypothesis, 572 consecutive HCII samples were statistically evaluated to the null hypothesis cross-well was not present. In addition, 874 paired from patients followed by both and polymerase chain reaction (PCR) analysis compared. Results A Kendall's tau measure association among adjacent wells yielded a P value .016, rejecting no contamination. Analysis relative light unit values between 0.8 1.5 rejected at P = .077. Moreover, PCR positivity significantly higher for with above vs (P = .001). Conclusion Cross-well occurs during processing, some borderline positives. The proportion cases risk is low (
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