A weakly positive human papillomavirus Hybrid Capture II result correlates with a significantly lower risk of cervical intraepithelial neoplasia 2,3 after atypical squamous cells of undetermined significance cytology.

摘要: OBJECTIVE The Hybrid Capture II assay (hc2; QIAGEN, Inc) for high-risk human papillomavirus (hrHPV) is an in vitro nucleic acid hybridization using chemiluminescence the qualitative detection of hrHPV DNA cervical samples. Results are reported as a ratio relative light units (RLUs) to cutoff value based on positive control. Specimens with RLU ratios 1.0 or higher scored hrHPV. We tested hypothesis that positives low-positive (1-10) had lower prevalence intraepithelial neoplasia 2,3 (CIN 2,3) histologic follow-up. MATERIALS AND METHODS Relative unit 388 consecutive hrHPV-positive cytologic specimens interpreted atypical squamous cells undetermined significance (ASCUS) were reviewed. Individual compared outcome diagnosis cases colposcopic follow-up and tissue sampling (biopsy and/or endocervical curettage; n = 236). RESULTS Of 236 follow-up, 63 range 1 10; these, 53 (84.1%) negative CIN, 7 (11.1%) CIN 1, (1.6%) uncertain grade, 2 (3.2%) 2,3. difference between 10 versus over (17.3%) was significant (p =.0047). not =.67). CONCLUSIONS An less associated significantly biopsy after Pap test result ASCUS. much underlying patients who weakly HPV-positive may justify modification management algorithm this subset women