A randomized trial of induction chemotherapy plus high-dose radiation versus radiation alone in stage III non-small-cell lung cancer.
作者： Robert O. Dillman , Stephen L. Seagren , Kathleen J. Propert , Julio Guerra , Walter L. Eaton
DOI: 10.1056/NEJM199010043231403
关键词:
摘要: Abstract Background. For patients with locally or regionally advanced non-small-cell lung cancer radiation is the standard treatment, but survival remains poor. We therefore conducted a randomized trial to determine whether induction chemotherapy before irradiation improves survival. Methods. All had documented of Stage III disease established by clinical surgical staging. Eligibility requirements included excellent performance status, minimal weight loss, and visible on radiography. Patients randomly assigned group 1 received cisplatin (100 mg per square meter body-surface area given intravenously days 29) vinblastine (5 1, 8, 15, 22, then began therapy day 50 (60 Gy over 6-week period). 2 same it immediately no chemotherapy. Results. The eligible in (n = 7...
pubpeer.com参考文章(17)
J C Ruckdeschel, D M Finkelstein, B A Mason, R H Creech, Chemotherapy for metastatic non-small-cell bronchogenic carcinoma: EST 2575, generation V--a randomized comparison of four cisplatin-containing regimens. Journal of Clinical Oncology. ,vol. 3, pp. 72- 79 ,(1985) , 10.1200/JCO.1985.3.1.72
D G Payne, Non-small-cell lung cancer: should unresectable stage III patients routinely receive high-dose radiation therapy? Journal of Clinical Oncology. ,vol. 6, pp. 552- 558 ,(1988) , 10.1200/JCO.1988.6.3.552
E Rapp, J L Pater, A Willan, Y Cormier, N Murray, W K Evans, D I Hodson, D A Clark, R Feld, A M Arnold, Chemotherapy can prolong survival in patients with advanced non-small-cell lung cancer--report of a Canadian multicenter randomized trial. Journal of Clinical Oncology. ,vol. 6, pp. 633- 641 ,(1988) , 10.1200/JCO.1988.6.4.633
Carlos A. Perez, Kenneth Stanley, Graham Grundy, William Hanson, Philip Rubin, Simon Kramer, Luther W. Brady, James E. Marks, Ruheri Perez-Tamayo, G. Stephen Brown, Joseph P. Concannon, Marvin Rotman, Impact of irradiation technique and tumor extent in tumor control and survival of patients with unresectable non-oat cell carcinoma of the lung. Report by the radiation therapy oncology group Cancer. ,vol. 50, pp. 1091- 1099 ,(1982) , 10.1002/1097-0142(19820915)50:6<1091::AID-CNCR2820500612>3.0.CO;2-0
Kasi S. Sridhar, Elizabeth Donnelly, Combination antiemetics for cisplatin chemotherapy. Cancer. ,vol. 61, pp. 1508- 1517 ,(1988) , 10.1002/1097-0142(19880415)61:8<1508::AID-CNCR2820610806>3.0.CO;2-H
Clifton F. Mountain, Assessment of the role of surgery for control of lung cancer. The Annals of Thoracic Surgery. ,vol. 24, pp. 365- 373 ,(1977) , 10.1016/S0003-4975(10)63416-9
R Peto, M C Pike, P Armitage, N E Breslow, D R Cox, S V Howard, N Mantel, K McPherson, J Peto, P G Smith, Design and analysis of randomized clinical trials requiring prolonged observation of each patient. II. analysis and examples. British Journal of Cancer. ,vol. 35, pp. 1- 39 ,(1977) , 10.1038/BJC.1977.1
Frederick O. Stephens, The case for a name change from neoadjuvant chemotherapy to induction chemotherapy. Cancer. ,vol. 63, pp. 1245- 1246 ,(1989) , 10.1002/1097-0142(19890401)63:7<1245::AID-CNCR2820630702>3.0.CO;2-C
Carlos A. Perez, Thomas F. Pajak, Philip Rubin, Joseph R. Simpson, Mohammed Mohiuddin, Luther W. Brady, Ruheri Perez-Tamayo, Marvin Rotman, Long‐term observations of the patterns of failure in patients with unresectable non‐oat cell carcinoma of the lung treated with definitive radiotherapy report by the radiation therapy oncology group Cancer. ,vol. 59, pp. 1874- 1881 ,(1987) , 10.1002/1097-0142(19870601)59:11<1874::AID-CNCR2820591106>3.0.CO;2-Z
Peter C. O'Brien, Thomas R. Fleming, A multiple testing procedure for clinical trials. Biometrics. ,vol. 35, pp. 549- 556 ,(1979) , 10.2307/2530245