Regeneration of the central nervous system using endogenous repair mechanisms

摘要: Recent advances in developmental and stem cell biology have made regeneration-based therapies feasible as therapeutic strategies for patients with damaged central nervous systems (CNSs), including those spinal cord injuries, Parkinson disease, or stroke. These can be classified into two approaches: (i) the replenishment of lost neural cells (ii) induction axonal regeneration. The first approach includes activation endogenous (NSCs) adult CNS transplantation therapy. Endogenous NSCs been shown to give rise new neurons after insults, ischemia, sustained; this form neurogenesis followed by migration functional maturation neuronal cells, well responses glial vascular system play crucial roles repair mechanisms tissue. In review, we will summarize recent approaches using NSCs, results our own collaborative groups.