Vascular Regeneration Therapies for Spinal Cord Injury
作者： Naosuke Kamei
DOI: 10.1007/978-4-431-54502-6_24
关键词:
摘要: As a novel approach for spinal cord regeneration, we focused on the close interaction between nervous system and blood vessels described as “vascular niche.” In our studies, endothelial progenitor cells (EPCs) or cell populations containing EPCs were used treating injury (SCI) in anticipation of causing formation vascular niche. Here introduce outcomes following studies: (1) kinetics endogenous SCI, (2) transplantation Jagged1 deficit EPCs, (3) human CD133+ cells. Bone marrow (BMT) from Tie2/lacZ transgenic mice into wild-type with SCI showed recruitment bone injured participation recruited angiogenesis astrogliosis SCI. Transplantation derived knockout revealed contribution transplanted to enhancement through Jagged1-Notch signaling. Human ex vivo expanded promoted functional recovery after
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