Ex-vivo expanded human blood-derived CD133+ cells promote repair of injured spinal cord
作者： Naosuke Kamei , Sang-Mo Kwon , Cantas Alev , Kazuyoshi Nakanishi , Kiyotaka Yamada
DOI: 10.1016/J.JNS.2013.02.013
关键词:
摘要: Abstract Human blood-derived CD133 + cell populations, which are believed to represent a hematopoietic/endothelial progenitor fraction, have the ability promote repair of injured spinal cord in animal models. However, mechanisms by transplantation promotes regeneration remain be clarified. Another possible hurdle on way clinical applicability these cells is their scarce representation overall population mononuclear cells. We therefore analyzed and compared ex-vivo expanded human blood derived with freshly isolated as well corresponding − control respect using vitro assays into mouse injury model. In vitro, fresh formed endothelial (EPC) colonies, whereas no EPC colonies. vivo, administration enhanced angiogenesis, astrogliosis, axon growth functional recovery after injury. contrast, failed recovery, but moderately angiogenesis astrogliosis. addition, high-dose was highly effective induction regenerative processes at cord.
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