Targeting circadian PER2 as therapy in myocardial ischemia and reperfusion injury.

摘要: The cycle of day and night dominates life on earth. Therefore, almost all living organisms adopted a molecular clock linked to the light-dark cycles. It is now well established that this crucial for human health wellbeing. Disruption clockwork directly results in myriad disorders, including cardiovascular diseases. Further, onset many diseases such as acute myocardial infarction exhibits circadian periodicity with worse outcomes early morning hours. Based these observations, research community became interested manipulating treat In recent years, several exciting discoveries pharmacological agents or mechanisms targeting have paved way medicine's arrival current review will outline most therapeutic advances related rhythm protein Period2 (PER2) ischemia summarize future respective field.