An evaluation of the role of glutathione and its associated enzymes in the expression of differential sensitivities to antitumour agents shown by a range of human tumour cell lines.
作者： Louise K. Hosking , Richard D.H. Whelan , Sharon A. Shellard , Philip Bedford , Bridget T. Hill
DOI: 10.1016/0006-2952(90)90364-Q
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摘要: Glutathione and its associated enzyme activities have been quantitated in a series of human tumour continuous cell lines expressing range vitro sensitivities to certain antitumour agents. Fourteen different parental 15 various drug- X-ray-selected resistant sublines studied. Quantitative relationships between total glutathione levels related six clinically-useful drugs or X-rays, as judged by colony forming assays, determined linear regression analysis. A positive correlation has identified cisplatin. Adriamycin, X-rays. In addition, correlations were noted cisplatin peroxidase reductase for Adriamycin responses with respect activity, using cumene hydroperoxide substrate. However, no these differential methotrexate, etoposide, vincristine 5-fluorouracil cytotoxicities. Furthermore, direct relationship was apparent S-transferase any drug X-ray this lines. These data appear provide further evidence linking altered metabolism cytotoxicities
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