Evaluation of the Hydatid Cyst Membrane Permeability of Albendazole and Albendazole Sulfoxide-Loaded Solid Lipid Nanoparticles
作者： Shahrzad Soltani , Abdollah Rafiei , Zahra Ramezani , Mohammad Reza Abbaspour , Ali Jelowdar
DOI: 10.17795/JJNPP-34723
关键词:
摘要: Background: Albendazole (ABZ) and albendazole sulfoxide (ABZSO) have a basic role in the treatment of hydatid cysts. However, their poor solubility limited intestinal permeability are main problems formulation. Objectives: The preparation characterization ABZ ABZSO-loaded solid lipid nanoparticles (SLNs) to increase cyst membrane permeation by loading into SLNs. Materials Methods: First, SLNs were prepared micro emulsification high shear homogenization. Physicochemical formulations for particle size, polydispersity index, drug entrapment efficiency (EE) (DL), zeta potential, shape, stability, vitro release studies evaluated. Next, conventional on cysts was evaluated quantifying concentrations fluid using high-performance liquid chromatography (HPLC). Results: showed sizes < 180 nm, index values around 0.08 with narrow size distributions, EE (91%) ABZ-SLN (94%) ABZSO-SLN, ideal stabilities regard largely negative potentials. free drugs exhibited very fast initial time, but displayed biphasic pattern drug-loaded Greater achieved SLN preparations. Conclusions: ABZSO good physicochemical characterizations, controlled release, higher efficacy SLNs, promising this disease.
kowsarpub.com参考文章(57)
R. Ravichandran, In Vivo Pharmacokinetic Studies of Albendazole Nanoparticulate Oral Formulations for Improved Bioavailability International Journal of Green Nanotechnology: Biomedicine. ,vol. 2, ,(2010) , 10.1080/1943085X.2010.488200
Vivek Ranjan Sinha, Honey Goel, Saurabh Srivastava, Vinay Jindal, Solid Lipid Nanoparticles (SLN’S) – Trends and Implications in Drug Targeting International Journal of Advances in Pharmaceutical Sciences. ,vol. 1, ,(2010)
Rainer H Müller, Karsten Mäder, Sven Gohla, Solid lipid nanoparticles (SLN) for controlled drug delivery - a review of the state of the art. European Journal of Pharmaceutics and Biopharmaceutics. ,vol. 50, pp. 161- 177 ,(2000) , 10.1016/S0939-6411(00)00087-4
Juliana M. Chan, Pedro M. Valencia, Liangfang Zhang, Robert Langer, Omid C. Farokhzad, Polymeric nanoparticles for drug delivery. Methods of Molecular Biology. ,vol. 624, pp. 163- 175 ,(2010) , 10.1007/978-1-60761-609-2_11
Vijay C. Verma, Mayank Gangwar, Madhu Yashpal, Gopal Nath, Anticestodal Activity of Endophytic Pestalotiopsis sp. on Protoscoleces of Hydatid Cyst Echinococcus granulosus BioMed Research International. ,vol. 2013, pp. 308515- ,(2013) , 10.1155/2013/308515
Jafar Ezzati Nazhad Dolatabadi, Yadollah Omidi, Dusan Losic, Carbon Nanotubes as an Advanced Drug and Gene Delivery Nanosystem Current Nanoscience. ,vol. 7, pp. 297- 314 ,(2011) , 10.2174/157341311795542444
Juliana L. Duarte, Cinthia Furst, Débora R. Klisiowicz, Giseli Klassen, Adriana O. Costa, Morphological, genotypic, and physiological characterization of Acanthamoeba isolates from keratitis patients and the domestic environment in Vitoria, Espírito Santo, Brazil. Experimental Parasitology. ,vol. 135, pp. 9- 14 ,(2013) , 10.1016/J.EXPPARA.2013.05.013
R.H Müller, M Radtke, S.A Wissing, Nanostructured lipid matrices for improved microencapsulation of drugs International Journal of Pharmaceutics. ,vol. 242, pp. 121- 128 ,(2002) , 10.1016/S0378-5173(02)00180-1
Doaa A. Yones, Gamal A. Taher, Zedan Z. Ibraheim, In Vitro Effects of Some Herbs Used in Egyptian Traditional Medicine on Viability of Protoscolices of Hydatid Cysts Korean Journal of Parasitology. ,vol. 49, pp. 255- 263 ,(2011) , 10.3347/KJP.2011.49.3.255
Marina Claro de Souza, Juliana Maldonado Marchetti, Development of albendazole sulfoxide-loaded Eudragit microparticles: A potential strategy to improve the drug bioavailability Advanced Powder Technology. ,vol. 23, pp. 801- 807 ,(2012) , 10.1016/J.APT.2011.10.009