The virology and immunobiology of lymphocytic choriomeningitis virus infection.

摘要: Publisher Summary This chapter presents in molecular terms the explanation for immunologic events accompanying lymphocytic choriomeningitis (LCM) infection, including dual recognition of viral and histocompatibility antigens essential T cell action modulation expression result from immune response. It discusses important aspects nonimmunologic regulation infection particularly role defective interfering virus. Lymphocytic virus (LCMV) it causes are subjects biomedical investigation. First, this sporadically human illness. The study LCMV disease its natural murine host has provided initial findings to open new fields immunobiology, immunopathology, cell–cell recognition. apparent increased virulence on passage through hamsters fact that can be transmitted humans suggest concerns not only investigators working with but experimentalists who use or hamster tissues their studies.