Respiratory and sleep-related complications of multiple system atrophy.

摘要: PURPOSE OF REVIEW The purpose of this article is to provide a contemporary review sleep issues affecting patients with multiple system atrophy (MSA). RECENT FINDINGS Prodromal symptoms MSA may occur years prior diagnosis, including autonomic dysfunction such as orthostatic hypotension, urogenital dysfunction, rapid eye movement (REM) behavior disorder (RBD), and stridor. Patients also develop sleep-related respiratory disorders obstructive apnea (OSA), central (CSA), development stridor associated shortened lifespan sudden death, which be further accelerated by instability. appears follow 'prion-like' disease progression. SUMMARY rapidly progressive neurodegenerative characterized combination failure motor symptoms. often misdiagnosed the initial presentation mimics other disorders. There are diagnostic criteria identify possible, probable, definite MSA. REM RBD, In previous years, treatment consisted tracheostomy but did not address component CSA, commonly coexisted or developed later because destruction medullary chemoreceptors. Positive airway pressure effective alone in ameliorating obstruction at vocal cord level.