Reversibly blocked plasmin, t-PA hybrid fibrinolytic enzymes and pharmaceutical compositions and anti-thrombotic use thereof

作者: Jeffery H. Robinson , Ian Dodd

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摘要: A fibrinolytically active hybrid protein which comprises one chain of a 2-chain protease linked to different protease, or the same at least chains in being derived from such that has catalytic site essential for fibrinolytic activity is optionally blocked by removable blocking group.

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