Tissue plasminogen activator analogs having modified growth factor domains
作者： Yasunori Ikeda , Bjorn A. Nexo , Eileen R. Mulvihill , Patrick J. O'hara , Suguru Suzuki
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摘要: Tissue plasminogen activator analogs containing the growth factor domain of native t-PA, having at least one cysteine residue replaced with another amino acid. The t-PA may further contain a variety substitutions and/or modifications. Pharmaceutical compositions or more along physiologically acceptable carrier diluent are also disclosed.
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