The role of genetic polymorphisms of the Renin–Angiotensin System in renal diseases: A meta-analysis
作者： Georgia G. Braliou , Athina-Maria G. Grigoriadou , Panagiota I. Kontou , Pantelis G. Bagos
DOI: 10.1016/J.CSBJ.2014.05.006
关键词:
摘要: Renal failure has a complex phenotype resulting from an underlying kidney disease as well environmental and genetic factors. In the present study we performed systematic review meta-analyses to evaluate association of A1166C polymorphism Angiotensin II type 1 Receptor gene (AGTR1) with Chronic Kidney Disease (CKD), End Stage (ESRD), IgA Nephropathy (IgAN) Vesicoureteral Reflux (VUR) A1332G 2 (AGTR2) (VUR). We found that neither AGTR1 Α1166C, nor AGTR2 polymorphisms were significantly associated any aforementioned renal diseases, suggesting they cannot be used predictive markers in either general or subgroup ethnic populations.
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