Chloromethylisothiazolone/methylisothiazolone (CMI/MI) use test with a shampoo on patch-test-positive subjects Results of a multicentre double-blind crossover trial

摘要: A randomized, multicentre, double-blind, 2–period crossover study with 2 shampoos was performed on subjects patch-test-positive to 100 ppm CMI/MI. One shampoo preserved 15 a.i. CMI/MI, the other 0.3% imidazolidinyl urea (IU). 27 from 5 European dermatology clinics participated. 1 subject discontinued use after severe adverse reactions CMI/MI-preserved and did not evaluate shampoo. Another developed moderate symptoms its use, but tolerated lU-preserved for full 2–week period. or washes of these weeks without any untoward effects. However, majority had negative findings scalp, face, neck, hands both shampoos. The physicians' global evaluation data indicated that CMI/MI caused fewer skin problems than IU (38% versus 27%, n.s.), over 1/3 (35%) having no either preservative. current showed most previously sensitized can successfully Since some possibly IU, may develop clinical reactions, it would still be prudent clinician advise alternative products patients sensitivity a cosmetic ingredient. Full ingredient labelling will ensure this is possible. As overall rate effects in individuals low, studies nature should also conducted allergens. This helpful determining relevance patch test data.