The effects of chitosan oligosaccharide (GO2KA1) supplementation on glucose control in subjects with prediabetes

摘要: We aimed to evaluate the effect of chitosan oligosaccharide (GO2KA1) supplementation on glucose control in subjects with prediabetes. This study was a randomized, double-blind, placebo-controlled clinical trial. Subjects prediabetes were randomly assigned GO2KA1 intervention group or placebo for 12 weeks. assessed serum levels glucose, insulin, and C-peptide by 2 hour value 75 g oral tolerance test (OGTT), HbA1c, pro-inflammatory cytokines, plasma adiponectin at baseline after week intervention. The treatment showed significant decrease level 30 min (p = 0.013) 60 0.028). change compared 0.030). Also, HbA1c 0.023) cytokines (IL-6 TNF-α) reduced increased treatment. However, did not show any changes these biomarkers. In prediabetes, supplement may help postprandial control.