Effect of corosolic acid on postchallenge plasma glucose levels.

摘要: Corosolic acid (CRA) is a substance extracted from Lagerstroemia speciosa L. and has been reported to have biological activities in vitro experimental animal studies. In this study, 31 subjects were orally administered 10 mg CRA or placebo, on different occasions, capsule 5 min before the 75-g oral glucose tolerance test (OGTT) double-blind cross-over design. Nineteen had diabetes, seven impaired tolerance, one fasting glucose, four normal according 1998 WHO criteria. There no significant differences plasma levels 30 after administration. treatment showed lower 60 until 120 reached statistical significance at 90 min. we shown for first time that lowering effect postchallenge vivo humans.