Use of the mouse for the isolation and investigation of stomach-associated, spiral-helical shaped bacteria from man and other animals.

摘要: Summary Spiral-helical shaped bacteria other than Campylobacter pylori have been shown to infect the human stomach. The characteristic helical morphology of these appears be similar that found in stomachs many animal species. Early reports on gastric suggested rodents may useful for investigation and isolation stomach-associated bacteria. Therefore, anaesthetised mice were given, through a stomach tube, heavy suspension spiral-helical bacterium from cat, scrapings mucus primates, or homogenised whole-antral biopsy patient. At intervals after inoculation, biopsies examined by lightmicroscopy electronmicroscopy presence Significant colonisation was observed 40% 1 week, 80% 11 weeks, inoculation with suspensions cat isolate. Mice also successfully colonised spiral present material monkey. These observations suggest prove animals study are, as yet, non-cultivable analysis some attributes commonly thought involved colonisation.