Azathioprine and 6-mercaptopurine (6-MP) suppress the human mixed lymphocyte reaction (MLR) by different mechanisms.
作者： SA Al-Safi , JL Maddocks
DOI: 10.1111/J.1365-2125.1984.TB02366.X
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摘要: 6-MP inhibitory effects on the MLR were reversed by AIC (46%), adenine (32%), hypoxanthine (89%), adenosine (86%) and inosine (93%). AIC, adenine, had no effect azathioprine inhibition of MLR. Adenosine at 10 microM caused 29% reversal 100-400 Reversal suppression was decreased with delay addition. Guanine, xanthine guanosine or These results show that suppress different mechanisms.
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