Trametes versicolor Protein YZP Activates Regulatory B Lymphocytes – Gene Identification through De Novo Assembly and Function Analysis in a Murine Acute Colitis Model

作者: Yen-Chou Kuan , Ying-Jou Wu , Chih-Liang Hung , Fuu Sheu

DOI: 10.1371/JOURNAL.PONE.0072422

关键词:

摘要: Background Trametes versicolor (Yun-Zhi) is a medicinal fungus used as chemotherapy co-treatment to enhance anti-tumor immunity. Although the efficacies of T. extracts have been documented, active ingredients and mechanisms underlying actions these remain uncharacterized.

参考文章(50)
S.-I. Tanuma, T. Aoki, H. Sakagami, A. Simpson, Induction of immunopotentiation activity by a protein-bound polysaccharide, PSK (review). Anticancer Research. ,vol. 11, pp. 993- 999 ,(1991)
Koichi Yanaba, Jean-David Bouaziz, Takashi Matsushita, Takeshi Tsubata, Thomas F. Tedder, The Development and Function of Regulatory B Cells Expressing IL-10 (B10 Cells) Requires Antigen Receptor Diversity and TLR Signals Journal of Immunology. ,vol. 182, pp. 7459- 7472 ,(2009) , 10.4049/JIMMUNOL.0900270
Laurent Genestier, Morgan Taillardet, Paul Mondiere, Hanane Gheit, Chantal Bella, Thierry Defrance, TLR agonists selectively promote terminal plasma cell differentiation of B cell subsets specialized in thymus-independent responses. Journal of Immunology. ,vol. 178, pp. 7779- 7786 ,(2007) , 10.4049/JIMMUNOL.178.12.7779
Y Oguchi, K Matsunaga, H Kobayashi, Antimetastatic effects of PSK (Krestin), a protein-bound polysaccharide obtained from basidiomycetes: an overview. Cancer Epidemiology, Biomarkers & Prevention. ,vol. 4, pp. 275- 281 ,(1995)
Shinjiro Maruyama, Taiki Akasaka, Koji Yamada, Hirofumi Tachibana, Protein-bound polysaccharide-K (PSK) directly enhanced IgM production in the human B cell line BALL-1 Biomedicine & Pharmacotherapy. ,vol. 63, pp. 409- 412 ,(2009) , 10.1016/J.BIOPHA.2008.08.006
Yu-Li Lin, Yu-Chih Liang, Yu-Shan Tseng, Hsin-Yi Huang, Shu-Yu Chou, Ruey-Shyang Hseu, Ching-Tsan Huang, Bor-Luen Chiang, An immunomodulatory protein, Ling Zhi-8, induced activation and maturation of human monocyte-derived dendritic cells by the NF-κB and MAPK pathways Journal of Leukocyte Biology. ,vol. 86, pp. 877- 889 ,(2009) , 10.1189/JLB.0708441
Atsushi Mizoguchi, Emiko Mizoguchi, Hidetoshi Takedatsu, Richard S Blumberg, Atul K Bhan, Chronic intestinal inflammatory condition generates IL-10-producing regulatory B cell subset characterized by CD1d upregulation. Immunity. ,vol. 16, pp. 219- 230 ,(2002) , 10.1016/S1074-7613(02)00274-1
Jeffrey A. Martin, Zhong Wang, Next-generation transcriptome assembly Nature Reviews Genetics. ,vol. 12, pp. 671- 682 ,(2011) , 10.1038/NRG3068
Hui-Hsin Chang, Kuang-Yang Hsieh, Chen-Hao Yeh, Yuan-Ping Tu, Fuu Sheu, Oral administration of an Enoki mushroom protein FVE activates innate and adaptive immunity and induces anti-tumor activity against murine hepatocellular carcinoma International Immunopharmacology. ,vol. 10, pp. 239- 246 ,(2010) , 10.1016/J.INTIMP.2009.10.017
Yen-Chou Kuan, Tsai-Jen Wu, Che-Yu Kuo, Ju-Chun Hsu, Wen-Ying Chang, Fuu Sheu, Molecular Cloning of a New Immunomodulatory Protein from Anoectochilus formosanus which Induces B Cell IgM Secretion through a T-Independent Mechanism PLoS ONE. ,vol. 6, pp. e21004- ,(2011) , 10.1371/JOURNAL.PONE.0021004