Secondary structure and intron-promoter homology in globin-switching.
作者： D K Lavett
DOI:
关键词:
摘要: An extensive stem-loop structure was found in the A gamma-globin promoter region. Intron transcripts from epsilon-globin, gamma-globin, delta-globin, and beta-globin were complementary to loop sequence. model for globin-switching based upon changes DNA secondary intron transcript pairing proposed. Pairing of epsilon with anti-sense strand postulated result up-regulation whereas sense down-regulation. The is consistent known hemoglobin disorders can be extended account any series genes that are turned on off as development proceeds.
参考文章(10)
F Baralle, The primary structure of the human epsilon-globin gene. Cell. ,vol. 21, pp. 621- 626 ,(1980) , 10.1016/0092-8674(80)90425-0
J. A. Steitz, K. Jakes, How ribosomes select initiator regions in mRNA: base pair formation between the 3' terminus of 16S rRNA and the mRNA during initiation of protein synthesis in Escherichia coli. Proceedings of the National Academy of Sciences of the United States of America. ,vol. 72, pp. 4734- 4738 ,(1975) , 10.1073/PNAS.72.12.4734
J Slightom, Human fetal gγ- and Aγ-globin genes: Complete nucleotide sequences suggest that DNA can be exchanged between these duplicated genes Cell. ,vol. 21, pp. 627- 638 ,(1980) , 10.1016/0092-8674(80)90426-2
D.J. Weatherall, J.B. Clegg, Recent developments in the molecular genetics of human hemoglobin Cell. ,vol. 16, pp. 467- 479 ,(1979) , 10.1016/0092-8674(79)90022-9
R Spritz, Complete nucleotide sequence of the human δ-globin gene Cell. ,vol. 21, pp. 639- 646 ,(1980) , 10.1016/0092-8674(80)90427-4
Richard M Lawn, Argiris Efstratiadis, Catherine O'Connell, Tom Maniatis, The nucleotide sequence of the human β-globin gene Cell. ,vol. 21, pp. 647- 651 ,(1980) , 10.1016/0092-8674(80)90428-6
Alf Larsen, Harold Weintraub, An altered DNA conformation detected by S1 nuclease occurs at specific regions in active chick globin chromatin Cell. ,vol. 29, pp. 609- 622 ,(1982) , 10.1016/0092-8674(82)90177-5
Meinrad Busslinger, Nikos Moschonas, Richard A. Flavell, β+ Thalassemia: Aberrant splicing results from a single point mutation in an intron Cell. ,vol. 27, pp. 289- 298 ,(1981) , 10.1016/0092-8674(81)90412-8
Mark Groudine, Harold Weintraub, Propagation of globin DNAase i-hypersensitive sites in absence of factors required for induction: A possible mechanism for determination Cell. ,vol. 30, pp. 131- 139 ,(1982) , 10.1016/0092-8674(82)90019-8
Argiris Efstratiadis, James W Posakony, Tom Maniatis, Richard M Lawn, Catherine O'Connell, Richard A Spritz, Jon K Deriel, Bernard G Forget, Sherman M Weissman, Jerry L Slightom, Ann E Blechl, Oliver Smithies, Francisco E Baralle, Carol C Shoulders, Nicholas J Proudfoot, The structure and evolution of the human β-globin gene family Cell. ,vol. 21, pp. 653- 668 ,(1980) , 10.1016/0092-8674(80)90429-8