Inhaled nitric oxide in full-term and nearly full-term infants with hypoxic respiratory failure

摘要: Background Neonates with pulmonary hypertension have been treated inhaled nitric oxide because of studies suggesting that it is a selective vasodilator. We conducted randomized, multicenter, controlled trial to determine whether would reduce mortality or the initiation extracorporeal membrane oxygenation in infants hypoxic respiratory failure, Methods Infants born after gestation greater than equal 34 weeks who were 14 days old less, had no structural heart disease, and required assisted ventilation whose index was 25 higher on two measurements eligible for study. The randomly assigned receive at concentration 20 ppm 100 percent oxygen (as control). partial pressure arterial (PaO2) increased by mm Hg less 30 minutes studied response 80-ppm control gas, Results 121 group 114 similar base-line clinical characteristics. Sixty-four 46 died within 120 (P=0.006). Seventeen (P not significant), but significantly fewer received (39 vs. 54 percent, P=0.014). improvement PaO2 (mean [+/-SD] increase, 58.2+/-85.2 Hg, 9.7+/-51.7 controls; P Conclusions Nitric therapy reduced use oxygenation, apparent effect mortality, critically ill failure. (C) 1997, Massachusetts Medical Society.