Genistein inhibition of the growth of human breast cancer cells: Independence from estrogen receptors and the multi-drug resistance gene
作者： Greg Peterson , Stephen Barnes
DOI: 10.1016/0006-291X(91)91423-A
关键词:
摘要: The effect of isoflavones on the growth human breast carcinoma cell lines, MDA-468 (estrogen receptor negative), and MCF-7 MCF-7-D-40 positive), has been examined. Genistein is a potent inhibitor each line (IC50 values from 6.5 to 12.0 micrograms/ml), whereas biochanin A daidzein are weaker inhibitors 20 34 micrograms/ml). isoflavone beta-glucosides, genistin daidzin, have little greater than 100 presence estrogen not required for inhibit tumor (MDA-468 vs cells). In addition, effects genistein attenuated by overexpression multi-drug resistance gene product (MCF-7-D40
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