Articulating Spacers for the Treatment of Infected Total Knee Arthroplasty: Effect of Antibiotic Combinations and Concentrations

摘要: Performing 2-stage procedures using articulating antibiotic cement spacers to eradicate infection while providing pain relief and maintaining function has become common among many surgeons. Despite the efficacy of in treatment infected total knee arthroplasty, questions remain regarding dosing cement. The authors assessed their experience with different regimens concentrations for eradication infection. Sixty-nine arthroplasties an average follow up 31 months (range, 6-70 months) treated were retrospectively reviewed. Treatment groups divided according spacer agents used amount antibiotics added Low-dose defined as those incorporating less than 4 g per 40-g bag cement, high-dose or more High- vs low-dose a single multiple compared. overall rate was 88%. Dose dependency not detected that incorporated agents, multiple-agent produced comparable success rates despite frequent use patients impaired immune function. Further study optimal combinations into these is needed help minimize failures maximizing efficacy.