Megaloblastic Changes in the Cervical Epithelium
作者： Nancy Whitehead
DOI: 10.1001/JAMA.1973.03230120013003
关键词:
摘要: "Megaloblastic" abnormalities of cervicovaginal cells similar to those seen in severe folate and vitamin B12deficiency were found 22 (19%) 115 women taking oral contraceptive agents (combined estrogen-progestogen or progestogens only). Similar changes not observed any 51 controls these medications. The cytologic could be related hematologic findings serum B12concentrations. reverted normal improved markedly all eight patients treated with pharmacologic doses folic acid for three weeks. It is hypothesized that induce a localized interference metabolism at the end organ level.
sci-hub.se 参考文章(18)
A.Majid Shojania, Gloria J. Hornady, Philip H. Barnes, The effect of oral contraceptives on folate metabolism American Journal of Obstetrics and Gynecology. ,vol. 111, pp. 782- 791 ,(1971) , 10.1016/0002-9378(71)90489-3
David Z. Kitay, W.Budd Wentz, Cervical cytology in folic acid deficiency of pregnancy American Journal of Obstetrics and Gynecology. ,vol. 104, pp. 931- 938 ,(1969) , 10.1016/0002-9378(69)90682-6
M. E. Attwood, CYTOLOGY AND THE CONTRACEPTIVE PILL British Journal of Obstetrics and Gynaecology. ,vol. 73, pp. 662- 665 ,(1966) , 10.1111/J.1471-0528.1966.TB15549.X
M. M. Boddington, A. I. Spriggs, The epithelial cells in megaloblastic anaemias. Journal of Clinical Pathology. ,vol. 12, pp. 228- 234 ,(1959) , 10.1136/JCP.12.3.228
Fred B. Stifel, Robert H. Herman, Norton S. Rosensweig, Dietary regulation of glycolytic enzymes. IX. The effect of oral, intramuscular and conjugated sex steroids on jejunal glycolytic enzyme activities in normal and castrated male and female rats. Biochimica et Biophysica Acta. ,vol. 222, pp. 65- 70 ,(1970) , 10.1016/0304-4165(70)90351-X
ROY HERTZ, WM. W. TULLNER, QUANTITATIVE INTERFERENCE WITH ESTROGENINDUCED TISSUE GROWTH BY FOLIC ACID ANTAGONISTS1 Endocrinology. ,vol. 44, pp. 278- 282 ,(1949) , 10.1210/ENDO-44-3-278
R. HERTZ, W. H. SEBRELL, IMPAIRMENT OF RESPONSE TO STILBESTROL IN THE OVIDUCT OF CHICKS DEFICIENT IN L. CASEI FACTOR ("FOLIC ACID"). Science. ,vol. 100, pp. 293- 294 ,(1944) , 10.1126/SCIENCE.100.2596.293
Richard R. Streiff, Folate Deficiency and Oral Contraceptives JAMA. ,vol. 214, pp. 105- 108 ,(1970) , 10.1001/JAMA.1970.03180010047010
Fred B. Stifel, Robert H. Herman, Norton S. Rosenweig, Dietary regulation of glycolytic enzymes IV. Differential hormonal effects in male and female rat jejunum Biochimica et Biophysica Acta (BBA) - General Subjects. ,vol. 184, pp. 495- 502 ,(1969) , 10.1016/0304-4165(69)90263-3
IRENE T. KLINE, RALPH I. DORFMAN, Patricia McCreery, ESTROGEN STIMULATION OF THE OVIDUCT IN VITAMIN-DEFICIENT CHICKS Endocrinology. ,vol. 48, pp. 345- 357 ,(1951) , 10.1210/ENDO-48-4-345