Metal complexes of water soluble texaphyrins

摘要: The present invention involves water soluble hydroxy-substituted texaphyrins retaining lipophilicity, of formula (I) wherein: M is H, a divalent or trivalent metal cation; R1, R2, R3, R4 and R5 are independently OH, C n H(2n+1)O y OC where at least one has hydroxy substituent; the molecular weight any less than equal to about 1000 daltons; positive integer zero; zero (2n+ 1); N an between -20 +2. These expanded porphyrin-like macrocycles efficient chelators ions. Various (e.g., transition, main group, lanthanide) complexes texaphyrin derivatives have unusual solubility stability. They absorb light strongly in physiologically important region (i.e. 690-880 nm). enhanced relaxivity therefore useful magnetic resonance imaging. form long-lived triplet states high yield act as photosensitizers for generation singlet oxygen. Thus, they inactivation destruction human immunodeficiency virus (HIV-1), mononuclear other cells infected with such well tumor cells. soluble, yet retain sufficient lipophilicity so greater affinity lipid rich areas atheroma tumors. may be used imaging followed by photodynamic therapy treatment properties, coupled their chemical stability appreciable water, add usefulness.