Synergistic compositions useful as anti-tumor agents

作者: Jerome Mendeleyev , Ernest Kun , Eva Kirsten

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摘要: The subject invention provides for novel synergistic compositions useful inactivating viruses or inducing apoptosis in tumor cells and treating cancer retroviral infections. Generally, the comprise one a plurality of ligands that oxidatively attack zinc finger pADPRT combination with agents selected from group consisting of: decrease cellular levels glutathione non-covalently bind to nicotinamide site but do not effect ejection pADPRT.

参考文章(44)
Jerome Mendeleyev, Eva Kirsten, Alaeddin Hakam, Kalman G. Buki, Ernest Kun, Potential chemotherapeutic activity of 4-iodo-3-nitrobenzamide: Metabolic reduction to the 3-nitroso derivative and induction of cell death in tumor cells in culture Biochemical Pharmacology. ,vol. 50, pp. 705- 714 ,(1995) , 10.1016/0006-2952(95)00189-7
Hakam Alaeddin, Alexander Tseng, Jerome Mclick, 6-amino-1,2-benzopyrone antitumorigenic agents and method ,(1989)
Barrie Christian Charles Cantello, Harry Smith, Frank Peter Doyle, Derek Richard Buckle, 3-cyano-4-hydroxy coumarin derivatives ,(1976)
Barrie Christian Charles Cantello, Harry Smith, Frank Peter Doyle, Derek Richard Buckle, 2-Cyano indan-1,3-diones ,(1975)
Mark B. Noss, Rick Panicucci, Robert A. McClelland, Andrew M. Rauth, Preparation, toxicity and mutagenicity of 1-methyl-2-nitrosoimidazole. A toxic 2-nitroimidazole reduction product. Biochemical Pharmacology. ,vol. 37, pp. 2585- 2593 ,(1988) , 10.1016/0006-2952(88)90250-X
A Lever, H Gottlinger, W Haseltine, J Sodroski, Identification of a sequence required for efficient packaging of human immunodeficiency virus type 1 RNA into virions. Journal of Virology. ,vol. 63, pp. 4085- 4087 ,(1989) , 10.1128/JVI.63.9.4085-4087.1989