Alcohol alters IL-6 Signal Transduction in the CNS of Transgenic Mice with Increased Astrocyte Expression of IL-6.

摘要: Neuroimmune factors, including the cytokine interleukin-6 (IL-6), are important chemical regulators of central nervous system (CNS) function under both physiological and pathological conditions. Elevated expression IL-6 occurs in CNS a variety disorders associated with altered function, excessive alcohol use. Alcohol-induced production has been reported for several regions cerebellum. Cerebellar actions occur through mechanisms, but alcohol-induced changes signal transduction, transcription, translation known to play roles. is an activator transduction that regulates gene expression. Thus, could contribute cerebellar effects by altering expression, especially conditions chronic abuse, where levels be habitually elevated. To gain understanding on we studied activation/expression partners STAT3 (Signal Transducer Activator Transcription), CCAAT-enhancer binding protein (C/EBP) beta, p42/p44 mitogen-activated kinase (MAPK) at level. Cerebella transgenic mice express elevated astrocyte produced were studied. Results show intermittent exposure/withdrawal affect interact alter partners. The alcohol/IL-6 interactions may alcohol, whereas alone have relevance occurring IL-6.