CD80-CD28 signaling controls the progression of inflammatory colorectal carcinogenesis
作者： Marco Scarpa , Paola Brun , Melania Scarpa , Susan Morgan , Andrea Porzionato
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摘要: In patients with ulcerative colitis (UC) the cumulative risk of colon cancer is lower than actual rate dysplasia suggesting an efficient immune surveillance mechanism. Since co-stimulatory molecule CD80 overexpressed in dysplastic colonic mucosa UC and T-cell activation entails effective costimulation, we aimed to evaluate functional implication signaling UC-associated carcinogenesis. humans, observed that percentage CD80+ HLA-A+ IEC was increased patients. vitro, activated CD8+ T-cells through a CD80-dependent pathway. Finally, AOM/DSS-induced adenocarcinoma model inhibition significantly frequency extension high-grade dysplasia, whereas enhancing activity anti-CTLA4 antibody decreased dysplasia. conclusion, between represents key factor controlling progression from low high grade inflammatory
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