Modulation of the colonic epithelial cell responses and amelioration of inflammation by CD80 blockade in TNBS colitis
作者： Mythily Srinivasan , Don-Jon Summerlin
DOI: 10.1016/J.CLIM.2009.09.001
关键词:
摘要: Inflammatory bowel diseases (IBD) result from dysregulated immune responses to the luminal antigens initiated by colonic epithelial cells (CEC) and propagated activated CD4+ T cells. Biological therapies are being developed that suppress inflammation promote homeostasis. Treatment with CD80-competitive antagonist peptide (CD80-CAP) has been shown cell in multiple disease models. Here we investigated effect of CD80-CAP on CEC experimental colitis. Balb/c mice induced trinitrobenzene sulfonic acid (TNBS) colitis were administered CD80-CAP/control peptide/vehicle. Administration decreased microscopic restored expression TLR-2, 3, 4 5 mRNA physiological levels. Furthermore, treatment suppressed Th1cytokines enhanced Th2 mice. In conclusion, administration ameliorated TNBS reducing inflammatory infiltration modulating response potentially restoring mucosal tolerance.
elsevier.com
sci-hub.se 参考文章(37)
Cesar F. Ortega-Cava, Shunji Ishihara, Mohammad A. K. Rumi, Kousaku Kawashima, Norihisa Ishimura, Hideaki Kazumori, Jun Udagawa, Yasunori Kadowaki, Yoshikazu Kinoshita, Strategic compartmentalization of Toll-like receptor 4 in the mouse gut. Journal of Immunology. ,vol. 170, pp. 3977- 3985 ,(2003) , 10.4049/JIMMUNOL.170.8.3977
Carin C. Stamper, Yan Zhang, James F. Tobin, David V. Erbe, Shinji Ikemizu, Simon J. Davis, Mark L. Stahl, Jasbir Seehra, William S. Somers, Lidia Mosyak, Crystal structure of the B7-1/CTLA-4 complex that inhibits human immune responses Nature. ,vol. 410, pp. 608- 611 ,(2001) , 10.1038/35069118
Tobias Mueller, Tomohiro Terada, Ian M. Rosenberg, Oren Shibolet, Daniel K. Podolsky, Th2 cytokines down-regulate TLR expression and function in human intestinal epithelial cells Journal of Immunology. ,vol. 176, pp. 5805- 5814 ,(2006) , 10.4049/JIMMUNOL.176.10.5805
Hilde Cheroutre, IELs: enforcing law and order in the court of the intestinal epithelium Immunological Reviews. ,vol. 206, pp. 114- 131 ,(2005) , 10.1111/J.0105-2896.2005.00284.X
Martha TRIANTAFILOU, Klaus BRANDENBURG, Shoichi KUSUMOTO, Koichi FUKASE, Alan MACKIE, Ulrich SEYDEL, Kathy TRIANTAFILOU, Combinational clustering of receptors following stimulation by bacterial products determines lipopolysaccharide responses Biochemical Journal. ,vol. 381, pp. 527- 536 ,(2004) , 10.1042/BJ20040172
C. O. ELSON, Y. CONG, S. BRANDWEIN, C. T. WEAVER, R. P. McCABE, M. MAHLER, J. P. SUNDBERG, E. H. LEITER, Experimental Models to Study Molecular Mechanisms Underlying Intestinal Inflammation Annals of the New York Academy of Sciences. ,vol. 859, pp. 85- 95 ,(1998) , 10.1111/J.1749-6632.1998.TB11113.X
Matam Vijay-Kumar, Huixia Wu, Jesse Aitken, Vasantha L. Kolachala, Andrew S. Neish, Shanthi V. Sitaraman, Andrew T. Gewirtz, Activation of toll‐like receptor 3 protects against DSS‐induced acute colitis Inflammatory Bowel Diseases. ,vol. 13, pp. 856- 864 ,(2007) , 10.1002/IBD.20142
Dawn H. Loh, Catalina Abad, Christopher S. Colwell, James A. Waschek, Vasoactive Intestinal Peptide Is Critical for Circadian Regulation of Glucocorticoids Neuroendocrinology. ,vol. 88, pp. 246- 255 ,(2008) , 10.1159/000140676
JoAnne L. Greene, Gina M. Leytze, John Emswiler, Robert Peach, Jürgen Bajorath, Wesley Cosand, Peter S. Linsley, Covalent Dimerization of CD28/CTLA-4 and Oligomerization of CD80/CD86 Regulate T Cell Costimulatory Interactions Journal of Biological Chemistry. ,vol. 271, pp. 26762- 26771 ,(1996) , 10.1074/JBC.271.43.26762
Mythily Srinivasan, Rajaraman Eri, Susan L. Zunt, Don-John Summerlin, David D. Brand, Janice S. Blum, Suppression of immune responses in collagen-induced arthritis by a rationally designed CD80-binding peptide agent Arthritis & Rheumatism. ,vol. 56, pp. 498- 508 ,(2007) , 10.1002/ART.22324