Studies on the anti-tumour activity of aliphatic aldehydes—V.

摘要: Abstract The in vitro study of kinetics the incorporation labelled amino acids into protein normal and neoplastic tissues has demonstrated that l - erythro -α,β-dihydroxybutyraldehyde ( -DHBA), at concentrations which do not appreciably affect cell respiration, inhibits a preferential way synthesis tumours. In presence 5 mM -DHBA, leucine large number tumours is completely inhibited during 2 nd hr incubation. Under same experimental conditions, acid incor poration rate various decreases as compared to controls, but it never blocked. A relationship between sensitivity aldehyde been observed are affected by drug independently their histogenetic origin. -DHBA only substance acts preferentially on comparative effect 3 4 -carbon aliphatic aldehydes rat liver Yoshida ascites hepatoma α-hydroxybutyraldehyde, β-hydroxybutyraldehyde, α,β-dihydroxybutyraldehyde its structural isomers more active than liver, while propionaldehyde, lactaldehyde, glyceraldehyde, n -butyraldehyde, iso crotonaldehyde, α-methylglyceraldehyde hepatoma. complete inhibition incubation -butyraldehyde. On whole, this data leads one conclude branching carbon chain C -aldehydes increases selective toxicity for whereas hydroxylation straight above-mentioned gives rise substances with action against