Inhibition of vascular endothelial growth factor in the treatment of colorectal cancer
作者： N FERNANDO , H HURWITZ
DOI: 10.1016/S0093-7754(03)70024-4
关键词:
摘要: Angiogenesis is essential for tumor growth and metastasis a promising target in the search new anti-neoplastic agents. tightly regulated process dependent on complex interplay between inhibitory stimulatory angiogenic factors. Vascular endothelial factor one of best characterized pro-angiogenic factors, multiple strategies have been developed to inhibit this pathway. Bevacizumab, monoclonal antibody against vascular factor, has shown initial preclinical clinical activity. This review will outline conceptual basis anti-angiogenic therapy, discuss critical role summarize available data use bevacizumab colorectal cancer.
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