Bisphenols (A, S, and F) affect the basic hormonal activity determined for pharmaceuticals – Study of Saccharomyces cerevisiae

摘要: Pharmaceuticals and analogs of bisphenol A (BPA) are increasingly threatening environmental pollutants. In this study, mixtures selected pharmaceuticals (diclofenac sodium salt, chloramphenicol, oxytetracycline hydrochloride, fluoxetine estrone, ketoprofen, progesterone, gemfibrozil androstenedione) were prepared with BPA its two (namely, bisphenols F S) at such ratios to reflect environmentally detectable levels. Then, the mixture solutions studied a XenoScreen YES/YAS assay determine variations in initial hormonal response each pharmaceutical compound due presence analog. The results obtained modeled concentration addition (CA) independent action (IA) approaches, trueness which was model deviation (MDR). estrogenic agonistic activity drugs most strongly affected by solution (twenty-one cases synergy observed for CA models versus twelve antagonism case IA predictions). BPS shows strong impact on medium high levels; androgenic also impaired elevated concentrations BPS. Increasing BPF reaction increased number YES + synergism incidences (for modeling). Estrone, progesterone androstenedione mostly highest research performed.