BR55: A Lipopeptide-Based VEGFR2-Targeted Ultrasound Contrast Agent for Molecular Imaging of Angiogenesis
作者： Sibylle Pochon , Isabelle Tardy , Philippe Bussat , Thierry Bettinger , Jean Brochot
DOI: 10.1097/RLI.0B013E3181C5927C
关键词:
摘要: Objectives:BR55, an ultrasound contrast agent functionalized with a heterodimer peptide targeting the vascular endothelial growth factor receptor 2 (VEGFR2), was evaluated in vitro and vivo, demonstrating its potential for specific tumor detection.Materials Methods:The targeted
sci-hub.se 参考文章(28)
Debbie J. Lee, Andrej Lyshchik, Jessica Huamani, Dennis E. Hallahan, Arthur C. Fleischer, Relationship Between Retention of a Vascular Endothelial Growth Factor Receptor 2 (VEGFR2)-Targeted Ultrasonographic Contrast Agent and the Level of VEGFR2 Expression in an In Vivo Breast Cancer Model Journal of Ultrasound in Medicine. ,vol. 27, pp. 855- 866 ,(2008) , 10.7863/JUM.2008.27.6.855
Napoleone Ferrara, Kenneth J Hillan, Hans-Peter Gerber, William Novotny, None, Discovery and development of bevacizumab, an anti-VEGF antibody for treating cancer Nature Reviews Drug Discovery. ,vol. 3, pp. 391- 400 ,(2004) , 10.1038/NRD1381
Paul A Dayton, Joshua J Rychak, Molecular ultrasound imaging using microbubble contrast agents Frontiers in Bioscience. ,vol. 12, pp. 5124- 5142 ,(2007) , 10.2741/2553
Gregory E. R. Weller, Flordeliza S. Villanueva, Alexander L. Klibanov, William R. Wagner, Modulating targeted adhesion of an ultrasound contrast agent to dysfunctional endothelium. Annals of Biomedical Engineering. ,vol. 30, pp. 1012- 1019 ,(2002) , 10.1114/1.1513565
M Chinol, P Casalini, M Maggiolo, S Canevari, ES Omodeo, P Caliceti, FM Veronese, M Cremonesi, F Chiolerio, E Nardone, AG Siccardi, G Paganelli, Biochemical modifications of avidin improve pharmacokinetics and biodistribution, and reduce immunogenicity British Journal of Cancer. ,vol. 78, pp. 189- 197 ,(1998) , 10.1038/BJC.1998.463
John Virostko, Jingping Xie, Dennis E Hallahan, Carlos L Arteaga, John C Gore, H Charles Manning, None, A Molecular Imaging Paradigm to Rapidly Profile Response to Angiogenesis-directed Therapy in Small Animals Molecular Imaging and Biology. ,vol. 11, pp. 204- 212 ,(2009) , 10.1007/S11307-008-0193-9
Jürgen K. Willmann, Amelie M. Lutz, Ramasamy Paulmurugan, Manishkumar R. Patel, Pauline Chu, Jarrett Rosenberg, Sanjiv S. Gambhir, Dual-targeted contrast agent for US assessment of tumor angiogenesis in vivo. Radiology. ,vol. 248, pp. 936- 944 ,(2008) , 10.1148/RADIOL.2483072231
Anke Reinacher-Schick, Michael Pohl, Wolff Schmiegel, Drug insight: antiangiogenic therapies for gastrointestinal cancers--focus on monoclonal antibodies. Nature Clinical Practice Gastroenterology & Hepatology. ,vol. 5, pp. 250- 267 ,(2008) , 10.1038/NCPGASTHEP1097
Marina V. Backer, Joseph M. Backer, Targeting endothelial cells overexpressing VEGFR-2: selective toxicity of Shiga-like toxin-VEGF fusion proteins. Bioconjugate Chemistry. ,vol. 12, pp. 1066- 1073 ,(2001) , 10.1021/BC015534J
Masabumi Shibuya, Differential roles of vascular endothelial growth factor receptor-1 and receptor-2 in angiogenesis. Journal of Biochemistry and Molecular Biology. ,vol. 39, pp. 469- 478 ,(2006) , 10.5483/BMBREP.2006.39.5.469