Selective de novo synthesis of tyrosine hydroxylase in organ cultures of rat superior cervical ganglia after in vivo administration of nerve growth factor.

摘要: Tyrosine hydroxylase is synthesized de novo in rat superior cervical ganglia organ culture. The differential rate of synthesis not increased significantly by the addition nerve growth factor to Prior administration vivo, however, leads an augmented tyrosine subsequently cultured vitro. was a between 3 and 4. Increases were detected within 6 h; reached maximum 24 36 h after single injection factor. Administration actinomycin D or antibody vivo prevented factor-induced increase However, synthetic