Update on the Biology and Therapy of Gastrointestinal Stromal Tumors

作者: Gina D'amato , Dejka M. Steinert , John C. Mcauliffe , Jonathan C. Trent

DOI: 10.1177/107327480501200106

关键词:

摘要: … Gastrointestinal stromal tumors (GISTs) are the most common mesenchymal tumors of the gastrointestinal tract. Over 85% of GISTs express the KIT receptor (stem cell factor receptor, …

参考文章(81)
Martin Carroll, Sayuri Ohno-Jones, Shu Tamura, Elisabeth Buchdunger, Jürg Zimmermann, Nicholas B. Lydon, D. Gary Gilliland, Brian J. Druker, CGP 57148, a Tyrosine Kinase Inhibitor, Inhibits the Growth of Cells Expressing BCR-ABL, TEL-ABL, and TEL-PDGFR Fusion Proteins Blood. ,vol. 90, pp. 4947- 4952 ,(1997) , 10.1182/BLOOD.V90.12.4947.4947_4947_4952
J. C. Trent, D. J. McConkey, S. M. Loughlin, M. T. Harbison, A. Fernandez, H. N. Ananthaswamy, Ras signaling in tumor necrosis factor-induced apoptosis. The EMBO Journal. ,vol. 15, pp. 4497- 4505 ,(1996) , 10.1002/J.1460-2075.1996.TB00827.X
P. Blume-Jensen, L. Claesson-Welsh, A. Siegbahn, K.M. Zsebo, B. Westermark, C.H. Heldin, Activation of the human c-kit product by ligand-induced dimerization mediates circular actin reorganization and chemotaxis. The EMBO Journal. ,vol. 10, pp. 4121- 4128 ,(1991) , 10.1002/J.1460-2075.1991.TB04989.X
Brian J. Druker, Elisabeth Buchdunger, Thomas Meyer, Marcel Müller, Nicholas B. Lydon, Helmut Mett, Jürg Zimmermann, Inhibition of the Abl Protein-Tyrosine Kinase in Vitro and in Vivo by a 2-Phenylaminopyrimidine Derivative Cancer Research. ,vol. 56, pp. 100- 104 ,(1996)
Hal E. Broxmeyer, Charlie Mantel, Gen Sheng Feng, Randy Shen, Mark S. Marshall, Tony Pawson, Tetsuzo Tauchi, THE UBIQUITOUSLY EXPRESSED SYP PHOSPHATASE INTERACTS WITH C-KIT AND GRB2 IN HEMATOPOIETIC CELLS Journal of Biological Chemistry. ,vol. 269, pp. 25206- 25211 ,(1994) , 10.1016/S0021-9258(17)31518-1
Jennifer L. Gommerman, Dino Sittaro, Nadia Z. Klebasz, David A. Williams, Stuart A. Berger, Differential stimulation of c-Kit mutants by membrane-bound and soluble Steel Factor correlates with leukemic potential. Blood. ,vol. 96, pp. 3734- 3742 ,(2000) , 10.1182/BLOOD.V96.12.3734.H8003734_3734_3742
Toshirou Nishida, Seiichi Hirota, Masahiko Taniguchi, Koji Hashimoto, Koji Isozaki, Harumi Nakamura, Yuzuru Kanakura, Tomoyuki Tanaka, Arimichi Takabayashi, Hikaru Matsuda, Yukihiko Kitamura, FAMILIAL GASTROINTESTINAL STROMAL TUMOURS WITH GERMLINE MUTATION OF THE KIT GENE Nature Genetics. ,vol. 19, pp. 323- 324 ,(1998) , 10.1038/1209
R.L. Cutler, L Liu, J.E. Damen, G Krystal, Multiple cytokines induce the tyrosine phosphorylation of Shc and its association with Grb2 in hemopoietic cells. Journal of Biological Chemistry. ,vol. 268, pp. 21463- 21465 ,(1993) , 10.1016/S0021-9258(20)80558-4
S Majumder, K Brown, F H Qiu, P Besmer, c-kit protein, a transmembrane kinase: identification in tissues and characterization. Molecular and Cellular Biology. ,vol. 8, pp. 4896- 4903 ,(1988) , 10.1128/MCB.8.11.4896