Efficacy of chloroquine, amodiaquine, sulfadoxine-pyrimethamine, chloroquine-sulfadoxine-pyrimethamine combination, and amodiaquine-sulfadoxine-pyrimethamine combination in Central African children with noncomplicated malaria.
作者： DIDIER MENARD , MAX ROGER KOULA , ANTOINE TALARMIN , NESTOR MADJI , ALEXANDRE MANIRAKIZA
DOI: 10.4269/AJTMH.2005.72.581
关键词:
摘要: This paper reports a two-phase study in Bangui, Central African Republic (CAR): first, we assessed the clinical efficacy to chloroquine (CQ), sulfadoxine-pyrimethamine (SP), and amodiaquine (AQ), then tested of two combinations: CQ + SP AQ SP. We used standard 14-day WHO 2001 protocol compare therapeutic responses children under 5 years age with acute uncomplicated Plasmodium falciparum malaria Bangui between February 2002 March 2004. The overall treatment failure rates CQ, AQ, SP, were 40.9%, 20.0%, 22.8%, 7.2%, 0%. These findings suggest that Ministry Health should recommend an interim policy combination as first-line antimalarial drug until best alternative treatments like artemisinin-based therapies (ACTs) become available at low prices CAR.
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