Physiological implications of estrogen receptor modulation by 2,3,7,8-tetrachlorodibenzo-p-dioxin.
作者： Thomas H. Umbreit , Michael A. Gallo
DOI: 10.1016/0378-4274(88)90097-5
关键词:
摘要: The interactions of 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) with hormones and hormone receptors have important implications for TCDD toxicity. Evidence suggests that modulates glucocorticoids, prolactin, thyroxine, low density lipids, epidermal growth factor, estrogens. Estrogen receptor modulation the animal's physiological responses to this appear be particularly effects can explain much toxicity observed in TCDD-treated animals. Susceptibility different species correlates their steroid glucuronidation capacity. Because close interdependent regulation hormonal systems, other may a similar role
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