IgG4 antibodies and cancer-associated inflammation: Insights into a novel mechanism of immune escape.
作者： Panagiotis Karagiannis , Amy E Gilbert , Frank O Nestle , Sophia N Karagiannis
DOI: 10.4161/ONCI.24889
关键词:
摘要: The role of B cells and antibodies in cancer is insufficiently understood but receiving increasing attention. We have recently identified IgG4 as an antibody subclass elicited by melanoma-associated interleukin-10-driven inflammation. In this setting, exhibit inefficient immunostimulatory capacity block the cytotoxic activities other antibodies. These previously unappreciated mechanisms immune escape may constitute promising targets for development novel anticancer immunotherapies.
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