A microscopic study of granulation mechanisms and their effect on granule properties

摘要: Abstract Classical granulation theory recognises wetting and nucleation, consolidation growth, breakage attrition as mechanisms that contribute to the formation of granules during high shear granulation. Each these may become dominant at different times in granulation, have a strong impact on evolution granule structure properties. This work has been conducted investigate microscopic, single scale, their effect uniformity structure, binder content, porosity, dissolution rate strength. It was found significant inhomogeneity existed properties, even for same size taken from batch sampling time. led conclusion takes place through concurrent competing mechanisms. some form coalescence resulting “Coalescence Granules” are more porous, weaker, lower content dissolve fast. Similarly sized also “Consolidation less porous slowly. is important this source properties should be considered process development, endpoint determination control therefore highlights importance understanding individual rates coalescence, if classical successfully translated into common industrial practice.