Propofol reduces MMPs expression by inhibiting NF-κB activity in human MDA-MB-231 cells.
作者： Qing Li , Lei Zhang , Youqun Han , Zhen Jiang , Qingxiu Wang
DOI: 10.1016/J.BIOPHA.2011.10.006
关键词:
摘要: Propofol is a common clinical anesthesia agent which now widely used in relieving pain of patients with chronic cancer as an adjuvant therapy. In our study, we found another effect propofol the therapy patients. We breast cell lines to detect effects and molecular mechanisms clinically relevant concentrations propofol, finding that reduced level MMP by inhibition NF-κB pathways, restrained migration invasion cells significantly. Our provides new sight into treatment and, suggesting not only can be reduces but plays important role inhibiting
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