Signal Transducer and Activator of Transcription-5 Activation and Breast Cancer Prognosis

作者: Marja T. Nevalainen , Jianwu Xie , Joachim Torhorst , Lukas Bubendorf , Philippe Haas

DOI: 10.1200/JCO.2004.11.046

关键词:

摘要: Purpose Transcription factor signal transducer and activator of transcription-5 (Stat5) promotes breast epithelial cell differentiation. We retrospectively analyzed whether levels active Stat5 in cancer were linked to clinical outcome. Materials Methods Immunohistochemistry was used detect active, tyrosine-phosphorylated paraffin-embedded specimens from three archival tissue microarray materials A, B, C. Material A included 19 healthy human tissues a progression series primary lymph node-negative, node-positive, metastatic (n = 400). B 785) C 570) represented two independent arrays unselected with follow-up data. Results demonstrated that activation, but not protein expression, gradually lost during progression, detectable activation 100% compared less than 20% node-positiv...

参考文章(30)
Steeg Ps, MacDonald Nj, Freije Jm, Nm23 and tumour metastasis: basic and translational advances. Biochemical Society symposium. ,vol. 63, pp. 261- 271 ,(1998)
Andreas Widschwendter, Thomas Welte, Günter Daxenbichler, Sibylle Tonko-Geymayer, Wolfgang Doppler, Christian Marth, Prognostic Significance of Signal Transducer and Activator of Transcription 1 Activation in Breast Cancer Clinical Cancer Research. ,vol. 8, pp. 3065- 3074 ,(2002)
David E Rivadeneira, Rache M Simmons, Paul J Christos, Kayane Hanna, John M Daly, Michael P Osborne, Predictive factors associated with axillary lymph node metastases in T1a and T1b breast carcinomas: analysis in more than 900 patients. Journal of The American College of Surgeons. ,vol. 191, pp. 1- 6 ,(2000) , 10.1016/S1072-7515(00)00310-0
E. L. Kaplan, Paul Meier, Nonparametric Estimation from Incomplete Observations Springer Series in Statistics. ,vol. 53, pp. 319- 337 ,(1992) , 10.1007/978-1-4612-4380-9_25
Ion Cotarla, Shuxun Ren, Ying Zhang, Edmund Gehan, Baljit Singh, Priscilla A. Furth, Stat5a is tyrosine phosphorylated and nuclear localized in a high proportion of human breast cancers International Journal of Cancer. ,vol. 108, pp. 665- 671 ,(2004) , 10.1002/IJC.11619
Jianwu Xie, Matthew J. LeBaron, Marja T. Nevalainen, Hallgeir Rui, Role of tyrosine kinase Jak2 in prolactin-induced differentiation and growth of mammary epithelial cells. Journal of Biological Chemistry. ,vol. 277, pp. 14020- 14030 ,(2002) , 10.1074/JBC.M112399200
Khandan Keyomarsi, Susan L. Tucker, Thomas A. Buchholz, Matthew Callister, Ye Ding, Gabriel N. Hortobagyi, Isabelle Bedrosian, Christopher Knickerbocker, Wendy Toyofuku, Michael Lowe, Thaddeus W. Herliczek, Sarah S. Bacus, Cyclin E and Survival in Patients with Breast Cancer The New England Journal of Medicine. ,vol. 347, pp. 1566- 1575 ,(2002) , 10.1056/NEJMOA021153
Stephan Teglund, Catriona McKay, Erin Schuetz, Jan M van Deursen, Dimitrios Stravopodis, Demin Wang, Michael Brown, Sara Bodner, Gerard Grosveld, James N Ihle, Stat5a and Stat5b Proteins Have Essential and Nonessential, or Redundant, Roles in Cytokine Responses Cell. ,vol. 93, pp. 841- 850 ,(1998) , 10.1016/S0092-8674(00)81444-0