作者: Marja T. Nevalainen , Jianwu Xie , Joachim Torhorst , Lukas Bubendorf , Philippe Haas
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摘要: Purpose Transcription factor signal transducer and activator of transcription-5 (Stat5) promotes breast epithelial cell differentiation. We retrospectively analyzed whether levels active Stat5 in cancer were linked to clinical outcome. Materials Methods Immunohistochemistry was used detect active, tyrosine-phosphorylated paraffin-embedded specimens from three archival tissue microarray materials A, B, C. Material A included 19 healthy human tissues a progression series primary lymph node-negative, node-positive, metastatic (n = 400). B 785) C 570) represented two independent arrays unselected with follow-up data. Results demonstrated that activation, but not protein expression, gradually lost during progression, detectable activation 100% compared less than 20% node-positiv...