Modeling of Drug Release from a Novel Temperature-Responsive Phase-Transient Drug Delivery System in Cylindrical Coordinates

摘要: In this study, a novel phase-transient multilayer drug delivery system responsive to unique stimulus, i.e., temperature, was introduced in cylindrical coordinates. The is composed of three individual sections, including the core, intermediate layer, and protecting polymeric coverage. layer gives smartness creates an “On-Off” release profile with increasing or decreasing environmental temperature around melting point layer. response mathematically modeled by analyzing heat mass transfer equations pseudo-steady state effects various parameters on performance were investigated. modeling results showed intensity different kinds factors, geometrical characteristics (e.g., radius core thicknesses layers), physical properties matrix ...