Transvascular fluid balance in the lung

摘要: 1. The transvascular fluid balance has been studied in isolated blood-perfused lungs of rabbit and cat. During periods left atrial pressure (LAp) elevation, changes preparation weight were measured. In some experiments simultaneous recordings blood volume, as judged by emitted radioactivity from 51Cr labelled red cells, performed. 2. nine out eleven experiments, elevation LAp 5 mm Hg within a test period 8 min resulted new stability thus apparently the establishment equilibrium. five these was also obtained on 10 Hg. When elevated further, equilibrium not obtained, continuous eventually progressive outward flux occurred. 3. with vasculature paralysed papaverine order to avoid vasomotor reactions, plasma protein content caused immediate alterations slopes preparations. These interpreted being due transfer. Again stable weights moderate content. 4. New equilibria seemed be reached result very small fluxes fluid. lung may dynamically maintained such Starling hypothesis could account for this balance, provided that shift can cause sufficiently marked osmotic and/or hydrostatic gradient across wall exchange vessels. 5. possible role extravascular compartment high colloid is discussed relation lung.