The Evolving Concept of Oxidative Stress

摘要: The metaphoric concept of oxidative stress has been fundamental to knowledge systematization in the field redox processes biomedicine. Oxidative evolved over recent years account for a disruption signaling and equilibrium, rather than just plain imbalance between prooxidants antioxidants causing molecular damage. Redox documented as potent ubiquitous mode regulation several important physiological events, its dysregulation accounts disease pathophysiology. However, there are yet unclear aspects regarding mechanisms whereby redox-related intermediates modulate targets at required level specificity robustness. Thus, itself is also an evolving entity. model ROS-mediated differential thiol solely on basis distinct chemical reactivities groups not able fully variety sophistication redox-dependent responses. current models have take into additional hierarchical levels cell biology realm. notion compartmentalization example this direction, here we tied it systems biology–based idea modularity. In context, may be viewed modular architecture consequent emergence supramodular secondary signaling. Further contextualizing these essential order allow meaningful progress strategies aiming improving detection disrupted or therapeutic interventions. These considerations indicate that, while having lost some metaphorical strength with respect mechanistical insights, dynamically reformulated remains powerful operational tool communicate contextualize science field.